Related Experiment Video
Updated: Jul 5, 2026

Particles without a Box: Brush-first Synthesis of Photodegradable PEG Star Polymers under Ambient Conditions
Published on: October 10, 2013
One-pot multi-component asymmetric cascade reactions catalyzed by soluble star polymers with highly branched
Yonggui Chi1, Steven T Scroggins, Jean M J Fréchet
1Division of Materials Sciences, Lawrence Berkeley National Laboratory, and College of Chemistry, University of California, Berkeley, California 94720-1460, USA.
Abstract:
Non-interpenetrating star polymer catalysts designed to mimic the site isolation characteristics of enzymes enable the one-pot combination of multiple otherwise incompatible catalysts for asymmetric cascade reactions that involve iminium, enamine, and H-bonding catalysis. Control experiments replacing star polymer catalysts with the corresponding small molecule or linear polymer analogues lead to little or no cascade reaction. Our strategy also allows straightforward access to all possible stereoisomers of the cascade product individually by proper choice of catalyst chirality. To our knowledge, this work represents the most sophisticated study of soluble polymers for site isolation, enzyme-like catalysis that generates cascade products with multiple chiral centers.
More Related Videos
09:02Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization
Published on: July 9, 2015
11:42Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
Published on: June 20, 2019
Related Concept Videos
Cationic Chain-Growth Polymerization: Mechanism
Anionic Chain-Growth Polymerization: Mechanism
Step-Growth Polymerization: Overview
Many natural and synthetic polymers are produced by...
Ziegler–Natta Chain-Growth Polymerization: Overview
Anionic Chain-Growth Polymerization: Overview
Radical Chain-Growth Polymerization: Mechanism