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[Disorder of the regulation of metabolic processes in coronary arteriosclerosis]
Insights
Cortisol influences adenylcyclase enzyme activity in platelets and lipid tissue, impacting lipoprotein transformation in patients with coronary atherosclerosis.
Area of Science:
- Biochemistry
- Endocrinology
- Cardiovascular Science
Context:
- Investigates the role of cortisol in cardiovascular disease.
- Examines enzyme activity in thrombocytes and lipid tissue.
- Assesses lipoprotein metabolism in relation to cortisol levels.
Purpose:
- To determine the effect of cortisol on adenylcyclase and phosphodiesterase activity.
- To analyze cortisol's impact on lipoprotein transformation.
- To understand the biochemical mechanisms underlying coronary atherosclerosis.
Summary:
- Cortisol's effect on adenylcyclase system enzymes in thrombocytes and lipid tissue was studied.
- Lipoprotein levels (low and very low density) were monitored before and after cortisol administration in rabbits.
- Clinical and experimental data indicate cortisol influences these enzymes and lipoprotein metabolism.
Impact:
- Provides insights into the biochemical pathways affected by cortisol in cardiovascular disease.
- Highlights potential therapeutic targets related to enzyme activity and lipoprotein metabolism.
- Contributes to understanding the complex interplay between hormones and atherosclerosis.
Abstract:
The activity of adenylcyclase was determined in the thrombocytes of 54 male patients with Stage III coronary atherosclerosis. In 34 patients without signs of ischaemic heart disease the activity of adenylcyclase and phosphodiestherase and the amount of cortisol were determined in blood plasma. In 40 rabbits the same enzymes activity was determined in the thrombocytes and lipid tissue, as well as the amount of lipoproteins of low and very low density was determined in blood plasma prior to and following cortisol administration. The results of clinical and experimental studies have demonstrated that cortisol affects the activity of the adenylcyclase system enzymes in the thrombocytes and lipid tissue, as well as the transformation of lipoproteins in blood plasma.