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Related Experiment Video

Updated: Jul 5, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Threat processing in obsessive-compulsive disorder: evidence from a modified negative priming task.

Nader Amir1, Michelle Cobb, Amanda S Morrison

  • 1San Diego State University, Joint Doctoral Program in Clinical Psychology, San Diego, CA 92120, USA. namir@mail.sdsu.edu

Behaviour Research and Therapy
|April 25, 2008
PubMed
Summary

Individuals with obsessive-compulsive disorder (OCD) struggle with processing threat-related information, showing impaired learning compared to controls. This difficulty in learning contingencies may contribute to intrusive thoughts in OCD.

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Area of Science:

  • Cognitive Psychology
  • Clinical Psychology
  • Neuroscience

Background:

  • Obsessive-compulsive disorder (OCD) is characterized by intrusive thoughts.
  • Information processing biases in attention, memory, and learning may underlie these intrusions.
  • Negative priming (NP) paradigms can reveal attentional and learning mechanisms.

Purpose of the Study:

  • To investigate information processing biases in individuals with OCD.
  • To examine learning and attentional mechanisms using a modified NP paradigm.
  • To compare processing of OCD-relevant threat, positive, and neutral words between individuals with OCD and controls.

Main Methods:

  • A modified negative priming (NP) paradigm was employed.
  • Participants included 19 individuals with OCD (OCs) and 19 matched non-anxious controls (NACs).
  • Idiographically selected words (OCD-relevant threat, OCD-relevant positive, neutral) were presented.

Main Results:

  • Non-anxious controls (NACs) exhibited positive priming across all word types.
  • Individuals with OCD (OCs) showed positive priming only for neutral words.
  • OCs demonstrated no priming for positive words and negative priming (NP) for threat words.

Conclusions:

  • Individuals with OCD exhibit impaired contingency learning for threat-related information.
  • Difficulty in learning contingencies for OCD-relevant threat words may contribute to intrusive thoughts.
  • Findings suggest specific information processing deficits in OCD related to threat stimuli.