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Nuclear receptors and coregulators in inflammation and cancer

Jason S Lee1, Keun Il Kim, Sung Hee Baek

  • 1Department of Biological Sciences, Research Center for Functional Cellulomics, Seoul National University, Seoul 151-742, South Korea.

Cancer Letters
|April 25, 2008
PubMed

Insights

Nuclear receptors and coregulators influence gene expression in inflammation and cancer. Targeting inflammatory genes offers a promising strategy for developing novel cancer therapeutics.

Area of Science:

  • Molecular biology
  • Oncology
  • Biochemistry

Background:

  • Nuclear receptors and coregulators are key regulators of gene transcription.
  • Emerging evidence links these molecules to inflammatory gene expression and hormone-dependent cancer progression.

Purpose of the Study:

  • To review the intricate relationship between nuclear receptor signaling, inflammation, and cancer.
  • To highlight potential therapeutic targets within inflammatory pathways.

Main Methods:

  • Literature review of studies on nuclear receptors, coregulators, inflammation, and cancer.
  • Synthesis of current understanding of molecular mechanisms involved.

Main Results:

  • Nuclear receptors and coregulators play a significant role in modulating inflammatory responses.
  • Dysregulation of these pathways is implicated in the development and progression of various cancers.

Conclusions:

  • The interplay between nuclear receptor signaling and inflammation is crucial in cancer.
  • Inflammatory genes represent promising targets for the development of innovative cancer therapies.

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