Related Experiment Video
Updated: Jul 5, 2026
An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage
Published on: April 23, 2017
Pharmacokinetic MR analysis of the cartilage is influenced by field strength
Luis Martí-Bonmatí1, Roberto Sanz-Requena, Angel Alberich-Bayarri
1Radiology Department, Hospital Quirón Valencia, Spain. Luis.Marti@uv.es
Purpose:
To study if the pharmacokinetic parameters derived from dynamic contrast-enhanced magnetic resonance (DCE-MR) images of the patellar cartilage are influenced by the main magnetic field strength.
Materials And Methods:
DCE-MR images of the knee were obtained from 16 normal male subjects (eight cases in each 1.5 and 3T magnets). Also, four volunteers were evaluated in both equipments within 1 week. Cartilage pharmacokinetic parameters of vascular permeability (K(trans)), extraction ratio (k(ep)), extravascular extracellular space volume fraction (v(e)) and intravascular space volume fraction (v(p)) were obtained.
Results:
Statistically significant differences were observed between the 1.5 and 3T groups for K(trans) (mean+/-S.D.; 5.44+/-2.27 vs. 1.01+/-0.41, respectively) and v(e) (3.37+/-2.32 vs. 0.81+/-0.80). A difference in K(trans) was also present when the same controls were evaluated in both equipments. There were no significant differences for k(ep) and v(p) values. Reproducibility of the pharmacokinetic calculations, assessed with the 24 acquisitions, showed a very low test-retest root mean square coefficient of variation (0.13, 0.10, 0.23 and 0.18 for K(trans), k(ep), v(e) and v(p), respectively).
Conclusion:
Cartilage vascular permeability values are influenced by the MR field strength. This should be taken in consideration when analyzing this biomarker.
