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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

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Related Experiment Video

Updated: Jul 5, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Notch signaling in CD4 and CD8 T cell development.

Karen Laky1, B J Fowlkes

  • 1Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, MD 20892-0420, USA. klaky@niaid.nih.gov

Current Opinion in Immunology
|April 25, 2008
PubMed
Summary

Notch signaling is crucial for T cell development, enhancing T cell receptor signaling in immature cells. Further research is needed to understand its precise role in generating mature T cells.

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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

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Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells
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Area of Science:

  • Immunology
  • Cell Biology
  • Developmental Biology

Background:

  • Notch signaling regulates diverse biological processes, particularly in lymphocytes.
  • It is essential for T cell fate specification and early differentiation.
  • Notch's role in CD4 versus CD8 T lineage commitment is debated.

Purpose of the Study:

  • To investigate the role of Notch signaling in T cell development.
  • To clarify how Notch signaling influences T cell receptor (TCR) signal transduction.
  • To explore the mechanisms by which Notch facilitates T cell maturation.

Main Methods:

  • Studies using conditional Presenilin-deficient mice.
  • Analysis of T cell selection and maturation.
  • Investigation of TCR signal transduction potentiation.

Main Results:

  • Notch signaling promotes CD4 and CD8 T cell selection and maturation.
  • It potentiates TCR signal transduction in immature thymocytes.
  • Challenges to previous hypotheses regarding Notch's role in lineage commitment.

Conclusions:

  • Notch signaling plays a key role in potentiating TCR signaling for T cell maturation.
  • The exact mechanisms and pathways (canonical vs. non-canonical) require further investigation.
  • Conditional mutants and signaling intermediates are crucial for future studies.