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Updated: Jul 5, 2026

Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine
Published on: May 21, 2012
Homeostatic chemokines in development, plasticity, and functional organization of the intestinal immune system
Reinhold Förster1, Oliver Pabst, Günter Bernhardt
1Institute of Immunology, Hannover Medical School, Hannover, Germany. forester.reinhold@mh-hannover.de
Abstract:
In the past decade accumulating evidence supported the view that the immune system should be regarded as trust consisting of several branches. In this review, we will first introduce the architectural features comprising the intestinal immune system emphasising its plasticity and subsequently discuss the concepts describing its development. We then focus on the chemokine/receptor system as a key integrator managing coordinated migration of and communication among the cells mediating intestinal immunity. Thus, chemokines control development and maintain functionality of the intestinal immune system that is required to perform the unique balancing act between tolerating food, curtailing commensals activities and eliminating pathogenic infections.
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