Related Experiment Video

Updated: Jul 5, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

Psoriasis and dilated cardiomyopathy: coincidence or associated diseases?

Noa Eliakim-Raz1, Mony Shuvy, Chaim Lotan

  • 1Department of Cardiology, Hebrew University-Hadassah Medical School, Jerusalem, Israel. noaeliakim@gmail.com

Cardiology
|April 25, 2008
PubMed

Insights

Psoriasis patients show a higher prevalence of dilated cardiomyopathy. This suggests shared genetic or immune factors may link these conditions, impacting heart health.

Area of Science:

  • Cardiology
  • Immunology
  • Dermatology

Background:

  • Psoriasis is a prevalent immune-mediated skin condition.
  • Dilated cardiomyopathy is a serious heart condition with various potential causes.
  • The link between psoriasis and dilated cardiomyopathy is not well understood.

Observation:

  • A computerized search revealed an increased prevalence of cardiomyopathy, particularly dilated cardiomyopathy, in patients hospitalized with psoriasis.
  • Four patients with both psoriasis and dilated cardiomyopathy were identified.

Findings:

  • The study suggests an association between pre-existing psoriasis and dilated cardiomyopathy.
  • Potential shared genetic risk factors between psoriasis (especially psoriatic arthritis) and dilated cardiomyopathy are proposed.
  • Immune reactions and chronic inflammation in psoriasis may contribute to dilated cardiomyopathy progression.

Implications:

  • Further research into shared genetic and immune pathways could illuminate the pathogenesis of dilated cardiomyopathy.
  • Understanding these links may lead to improved treatment strategies for dilated cardiomyopathy in psoriatic patients.

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...