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Efficacy and tolerability of rosuvastatin and atorvastatin when force-titrated in patients with primary

Ole Faergeman1, Laurie Hill, Eberhard Windler

  • 1Aarhus Sygehus University Hospital, Aarhus, Denmark.

Cardiology
|April 25, 2008
PubMed

Insights

Force-titrated rosuvastatin (10-40 mg) significantly improved lipid profiles and helped more high-risk patients reach low-density lipoprotein cholesterol (LDL-C) goals compared to atorvastatin (10-80 mg). This study highlights rosuvastatin

Area of Science:

  • Cardiovascular disease
  • Lipid metabolism
  • Pharmacology

Background:

  • High-risk cardiovascular disease patients often do not achieve low-density lipoprotein cholesterol (LDL-C) targets due to suboptimal statin titration.
  • The ECLIPSE study investigated rosuvastatin versus atorvastatin in hypercholesterolemic patients.

Purpose of the Study:

  • To compare the efficacy and safety of force-titrated rosuvastatin (10-40 mg) against force-titrated atorvastatin (10-80 mg).
  • To assess the ability of each statin to help high-risk patients achieve LDL-C goals.

Main Methods:

  • A 24-week, open-label, randomized, multinational, parallel-group study.
  • 1,036 patients with hypercholesterolemia were randomized to rosuvastatin (n=522) or atorvastatin (n=514).

Main Results:

  • Significantly more patients on rosuvastatin achieved LDL-C goals (<100 mg/dl, <2.5/3.0 mmol/l, and <70 mg/dl) compared to atorvastatin (p < 0.001).
  • Rosuvastatin demonstrated superior improvements in the atherogenic lipid profile.
  • Both treatments were well-tolerated.

Conclusions:

  • Force-titrated rosuvastatin provides superior lipoprotein profile modification versus atorvastatin.
  • Rosuvastatin enables a greater proportion of high-risk patients to attain recommended LDL-C goals.
Abstract

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