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Updated: Jul 5, 2026
09:55
An In Vivo Murine Sciatic Nerve Model of Perineural Invasion
Published on: April 23, 2018
The normal and neoplastic perineurium: a review
Sergio Piña-Oviedo1, Carlos Ortiz-Hidalgo
1Laboratory of Cell and Tissue Biology, Universidad Panamericana School of Medicine, Donatello 59, Colonia Insurgentes Mixcoac, Mexico City, Mexico.
Advances in Anatomic Pathology
|April 25, 2008
Summary
The perineurium, a key nerve layer, plays roles in protection and forming the blood-nerve barrier. Perineuriomas, rare tumors of perineurial cells, require specific diagnostic markers for accurate identification.
Area of Science:
- Neuroscience
- Pathology
- Oncology
Background:
- The peripheral nervous system comprises three distinct layers: endoneurium, perineurium, and epineurium.
- The perineurium, continuous with the central nervous system's pia-arachnoid, forms concentric layers around nerve fascicles.
- It functions in modulating mechanical stress and establishing the blood-nerve barrier.
Purpose of the Study:
- To review the pathology of the perineurium and perineurial cell neoplasms.
- To highlight the diagnostic challenges and immunohistochemical markers for perineuriomas.
- To discuss the prognostic significance of perineurial invasion in malignancies.
Main Methods:
- Review of existing literature on perineurial anatomy, pathology, and neoplasms.
- Analysis of diagnostic criteria, including immunohistochemistry and ultrastructural studies.
- Examination of cytogenetic findings in perineuromas.
Main Results:
- Perineurial invasion is a critical prognostic indicator in various cancers.
- Perineuriomas are rare benign neoplasms with intraneural and extraneural variants.
- Typical perineuriomas exhibit specific immunohistochemical profiles (EMA, GLUT1, Claudin-1 positive; S-100, neurofilament negative).
Conclusions:
- Accurate diagnosis of perineuromas is crucial due to potential overlap with other spindle cell tumors.
- Immunohistochemistry is essential for differentiating perineuromas.
- Cytogenetic aberrations may correlate with specific perineuroma subtypes.
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