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[Relaxation and diastolic filling precisely evaluated in patients with left ventricular dysfunction]
1First Department of Internal Medicine, Mie University School of Medicine, Tsu.
Journal of Cardiology
|January 1, 1991
Summary
Left ventricular (LV) diastolic function is impaired in patients with LV dysfunction, affecting LV relaxation and early diastolic filling. Mitral regurgitation (MR) can modify diastolic filling but does not fully restore function.
Area of Science:
- Cardiology
- Physiology
Context:
- Left ventricular (LV) diastolic dysfunction is a key factor in heart failure.
- Assessing diastolic function is crucial for understanding LV mechanics.
Purpose:
- To evaluate left ventricular (LV) diastolic function in patients with LV systolic dysfunction.
- To differentiate the impact of LV dysfunction and mitral regurgitation (MR) on diastolic parameters.
Summary:
- LV relaxation and early diastolic filling were assessed in 27 patients with LV systolic dysfunction (ejection fraction ≤ 0.45) and 18 controls using LV pressures and biplane angiograms.
- LV relaxation was impaired in patients with LV dysfunction.
- While peak filling rate (PFR) and mean filling rate (MFR) were maintained, early diastolic filling was significantly decreased in patients without MR, but not in those with MR.
Impact:
- LV relaxation and early diastolic filling are fundamentally impaired in LV dysfunction.
- Mitral regurgitation (MR) can influence diastolic filling patterns but does not fully normalize impaired diastolic function.
- Findings highlight the complex interplay between LV dysfunction, MR, and diastolic mechanics.