[Study of bioactive nano-multiplayer films on medical stainless steel fabrication and haemocompatibility]

To improve the biocompatibility of metallic implants, bioactive nano-multilayer films consisting of polyethylenimine (PEI) and hyaluronan (HA) were prepared on biomedical 316L stainless steel surface via electrostatic self-assembly. Small angle X-ray diffraction curve revealed that multilayer films arranged regularly layer-by-layer. Atomic force micrcscopy (AFM) was applied to determine the surface topograph and roughness. The results showed that the coated surface became smoother with the increase of number of layers. Platelet adhesion experiment indicated that the nano-multilayer films significantly reduced the platelet adhesion on the surfaces and exhibited obviously improved haemocompatibility.