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Updated: Jul 5, 2026
Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
[Biological evaluation of new percutaneous implanting materials]
Min Tang1, Xiudong Yang, Yao Wu
1Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China. mingtangtang@yahoo.com.cn
Abstract:
According to ISO 10993 standard series, the biological safety of surface modified pure titanium was studied as a percutaneous device by the test of cytotoxicity in vitro, as well as by the tests of irritation and sensitization. The result from the examination of cytotoxicity in vitro was negative, the skin irritation response was negligible, and the result of test on skin sensitization in guinea pigs was also negligible. So the surface modified pure titanium in this study can be safely used as percutaneous implanting materials.
