[Lentiviral vectors and advance in its application]

Area of Science:

• Gene Therapy
• Molecular Biology
• Virology

Context:

• Lentiviral vectors (Lv) are a prominent research area in gene therapy due to their advantageous properties.
• These properties include efficient transduction of both dividing and non-dividing cells, large gene transfer capacity, and sustained gene expression.
• A low rate of immunological response further enhances their therapeutic potential.

Purpose:

• To review the fundamental characteristics of lentiviral vectors (Lv).
• To discuss the developmental advancements in Lv technology.
• To explore the current and emerging applications of Lv in gene therapy.

Summary:

• This review focuses on lentiviral vectors (Lv), particularly those derived from HIV-1.
• It details their structural features, evolutionary progress, and diverse applications in the field of gene therapy.
• Key aspects covered include transduction efficiency, gene capacity, expression duration, and immunogenicity.

Impact:

• Lentiviral vectors (Lv) represent a significant platform for developing novel gene therapies.
• Understanding their characteristics and applications is crucial for advancing therapeutic strategies.
• This review provides a comprehensive overview for researchers and clinicians in the gene therapy domain.