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Updated: Jul 5, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
Published on: January 11, 2020
[Fluorine-18 in radiopharmacy]
V de Beco1, D Le Bars, J-M Scherrmann
1Service de Radiopharmacie-phamacie, CHU d'Avicenne, 125, route de Stalingrad, 93009 Bobigny cedex, France. virginie.de-beco@avc.aphp.fr
Abstract:
Positron emission tomography (PET) is a recent and expanding functional nuclear imaging technique. Its extensive development is related to the radiophysical properties fluorine 18 (18F) (weak energy of positron, sufficiently long physical half-life) and to the simple production and labeling procedures for 18F. [18F]fluorodesoxyglucose was the first licensed radiopharmaceutical in France in 1998. [18F]fluoroDOPA was registered in 2006. Introduction of automated chemistry modules enable development of new fluorinated tracers.
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