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Soy consumption is not a risk factor for peanut sensitization.

Jennifer Koplin1, Shyamali C Dharmage, Lyle Gurrin

  • 1Murdoch Children's Research Institute, Melbourne, Australia.

The Journal of Allergy and Clinical Immunology
|April 26, 2008
PubMed
Summary
This summary is machine-generated.

Soy consumption does not cause peanut sensitization in children. The initial association was due to parents giving soy to infants with existing milk allergies or sensitivities.

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Area of Science:

  • Pediatric Allergy and Immunology
  • Nutritional Epidemiology
  • Infant Nutrition

Background:

  • Previous studies suggested a link between soy intake and peanut allergy.
  • This raised the possibility of dietary modifications for peanut allergy prevention.

Purpose of the Study:

  • To examine the prospective association between soy consumption and peanut sensitization in infants.
  • To determine if soy intake is an independent risk factor for developing peanut allergy.

Main Methods:

  • A cohort of 620 infants with a family history of allergy was followed.
  • Dietary intake, including soy formula/milk, was recorded via interviews up to age 2 years.
  • Peanut, milk, and egg sensitization was assessed using skin prick tests at 6, 12, and 24 months.

Main Results:

  • Initial analysis showed higher peanut sensitization in children consuming soy (OR, 2.02).
  • This association was attributed to soy being given to infants with milk allergy or sensitization.
  • After adjusting for milk allergy confounders, no significant link between soy and peanut sensitization was found (OR, 1.34).

Conclusions:

  • The observed association between soy consumption and peanut sensitization is not causal.
  • It is likely confounded by parental choices to use soy products in infants with existing milk allergies.
  • Future research on diet and childhood allergies must account for parental dietary modification behaviors.