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Updated: Jul 5, 2026

A Neonatal Mouse Spinal Cord Compression Injury Model
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Interaction between developing spinal locomotor networks in the neonatal mouse.

Ian T Gordon1, Mary J Dunbar, Kimberly J Vanneste

  • 1Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

Journal of Neurophysiology
|April 26, 2008
PubMed
Summary

Neonatal mouse cervical networks generate coordinated rhythmic patterns for forelimb locomotion independently of lower spinal cord segments. However, input from caudal segments influences cervical rhythm stability and pattern.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Locomotion

Background:

  • Mammalian spinal cord networks control locomotion.
  • Thoracosacral networks are well-studied, but cervicothoracic networks generating forelimb movement are less understood.

Purpose of the Study:

  • To investigate the capacity of neonatal mouse cervical networks to produce rhythmic patterns for forelimb locomotion.
  • To determine the influence of thoracosacral segments on cervical network activity.

Main Methods:

  • Used brain stem-spinal cord preparations from neonatal mice.
  • Recorded neurograms from cervical segments (C5, C8).
  • Performed spinal cord transections and pharmacological stimulations.

Main Results:

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Last Updated: Jul 5, 2026

A Neonatal Mouse Spinal Cord Compression Injury Model
13:31

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Spinal Cord Electrophysiology
04:59

Spinal Cord Electrophysiology

Published on: January 18, 2010

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

  • Cervical networks (C5, C8) exhibited alternating left-right and ipsilateral rhythmic activity, indicative of locomotor patterns.
  • These cervical patterns persisted after T5 transection, showing independence from thoracosacral segments.
  • Activation of thoracosacral networks induced rhythmic activity in cervical segments.
  • Cervicothoracic network activation modulated thoracosacral locomotor patterns, influencing rhythm and introducing oscillations.

Conclusions:

  • Neonatal mouse cervical central pattern generators (CPGs) can produce coordinated rhythmic patterns without caudal input.
  • Caudorostral drive from thoracosacral segments contributes to cervical pattern generation and rhythm stability.