Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Birth Control Methods01:22

Birth Control Methods

Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Accessory Glands of the Male Reproductive System01:16

Accessory Glands of the Male Reproductive System

The accessory ducts involved in sperm maturation and transportation include the epididymides, vasa deferentia, ejaculatory ducts, and urethra. These ducts play a critical role in the maturation, storage, and transportation of sperm from the testes to the urethra, where it is then released during ejaculation.
The epididymis is a small, comma-shaped organ located at the back of each testicle. The epididymis can be divided into three main parts: the head, body, and tail. The head of the epididymis...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kinetics of cortisol and cortisone binding to corticosteroid binding globulin and albumin <i>in vivo</i>.

bioRxiv : the preprint server for biology·2026
Same author

Cyclic Treatment With WIN 18,446, a Potential Male Contraceptive, is as Effective as Continuous Treatment for Suppression of Spermatogenesis in Mice.

Andrology·2026
Same author

Targeting donor XCR1+ and CD11b+ dendritic cells prevents Th1- and Th17-dependent GVHD within the gastrointestinal tract.

Blood·2026
Same author

Differential retinoic acid responses across testicular development <i>in vitro</i>.

bioRxiv : the preprint server for biology·2026
Same author

Development and Validation of a Novel LC-MS/MS-Based Proteomics Method for Quantitation of Retinol Binding Protein 4 (RBP4) and Transthyretin (TTR).

Journal of proteome research·2025
Same author

Curcumin enhances the oral bioavailability of testosterone by inhibiting its intestinal metabolism.

Drug metabolism and disposition: the biological fate of chemicals·2025

Related Experiment Video

Updated: Jul 5, 2026

Mouse Round Spermatid Injection
08:41

Mouse Round Spermatid Injection

Published on: January 26, 2024

Advances in male contraception.

Stephanie T Page1, John K Amory, William J Bremner

  • 1Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA. page@u.washington.edu

Endocrine Reviews
|April 26, 2008
PubMed
Summary
This summary is machine-generated.

Developing male contraceptives is crucial for global population management and environmental sustainability. Research shows hormonal and non-hormonal male birth control methods are highly effective and nearing clinical trials.

More Related Videos

Optimizing the Modified No-Scalpel Vasectomy Technique
04:47

Optimizing the Modified No-Scalpel Vasectomy Technique

Published on: October 18, 2024

High-Resolution Respirometry to Assess Mitochondrial Function in Human Spermatozoa
08:32

High-Resolution Respirometry to Assess Mitochondrial Function in Human Spermatozoa

Published on: June 23, 2023

Related Experiment Videos

Last Updated: Jul 5, 2026

Mouse Round Spermatid Injection
08:41

Mouse Round Spermatid Injection

Published on: January 26, 2024

Optimizing the Modified No-Scalpel Vasectomy Technique
04:47

Optimizing the Modified No-Scalpel Vasectomy Technique

Published on: October 18, 2024

High-Resolution Respirometry to Assess Mitochondrial Function in Human Spermatozoa
08:32

High-Resolution Respirometry to Assess Mitochondrial Function in Human Spermatozoa

Published on: June 23, 2023

Area of Science:

  • Reproductive Health
  • Contraception Development
  • Male Reproductive Physiology

Background:

  • Despite advances in female contraception, global population growth continues, exacerbating environmental issues and unplanned pregnancies.
  • Male contraceptive options are limited, yet men express willingness to participate, with current methods like condoms and vasectomy accounting for significant usage.
  • Existing male contraceptive research shows high efficacy rates for hormonal methods, but delivery and regulatory hurdles remain.

Purpose of the Study:

  • To review the current state and future prospects of male contraceptive development.
  • To highlight the need for expanded, reversible male contraceptive options to address global population and environmental concerns.
  • To discuss advancements in both hormonal and non-hormonal male contraceptive research.

Main Methods:

  • Review of recent international clinical research on male contraceptives.
  • Analysis of technological advancements in androgen delivery systems (oral, injectable).
  • Exploration of non-hormonal approaches targeting sperm motility using gene and protein array technologies.

Main Results:

  • Hormonally based male contraceptives have demonstrated high efficacy rates (90-95%) in clinical trials.
  • Advances in oral and injectable androgen delivery systems offer potential solutions to current delivery method limitations.
  • Non-hormonal methods targeting sperm motility are progressing, with potential targets identified for future clinical trials.

Conclusions:

  • Effective, reversible male contraception is a viable option for family planning within the next decade.
  • Overcoming delivery and regulatory barriers is key to market introduction of new male contraceptive methods.
  • Continued collaboration between scientists, clinicians, industry, and funding agencies is essential for advancing male contraceptive development.