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Updated: Jul 5, 2026

Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers
Published on: October 21, 2018
Epigenetic regulation of vascular endothelial gene expression
Charles C Matouk1, Philip A Marsden
1Institute of Medical Sciences, St. Michael's Hospital and University of Toronto, Ontario, Canada.
Abstract:
Epigenetics refers to chromatin-based pathways important in the regulation of gene expression and includes 3 distinct, but highly interrelated, mechanisms: DNA methylation, histone density and posttranslational modifications, and RNA-based mechanisms. Together, they offer a newer perspective on transcriptional control paradigms in vascular endothelial cells and provide a molecular basis for how the environment impacts the genome to modify disease susceptibility. This review provides an introduction to epigenetic concepts for vascular biologists. Using endothelial nitric oxide synthase (NOS3) as an example, we examine the growing body of evidence implicating epigenetic pathways in the control of vascular endothelial gene expression in health and disease.
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