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Transient Middle Cerebral Artery Occlusion Model of Stroke
Published on: August 11, 2023
Transient directional disorientation as a manifestation of cerebral ischemia
Tadashi Ino1, Hideo Usami, Kazuki Tokumoto
1Department of Neurology, Rakuwakai-Otowa Hospital, Kyoto, Japan. rakuwadr042@rakuwadr.com
Abstract:
The authors describe 2 patients who presented with transient directional disorientation (TDD) as a manifestation of cerebral ischemia. The patients suddenly lost sense of direction in a familiar environment despite preserved ability to recognize landmarks, and recovered within a short time. Brain MRI revealed an ischemic lesion in the right medial occipital lobe and the corpus callosum in case 1 and in the right parieto-occipital sulcus (POS) in case 2. After ictus, fMRI study of a navigation task was performed, which demonstrated the activation of the POS unilaterally in case 1 and bilaterally in case 2. We propose that TDD of our patients is related to temporary dysfunction of bilateral POS.
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