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Related Concept Videos

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Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Jul 5, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Optic disc cupping after optic neuritis evaluated with optic coherence tomography.

G Rebolleda1, S Noval, I Contreras

  • 1Ophthalmology Department, Glaucoma Unit, Hospital Ramón y Cajal, Madrid, Spain. grebolleda@telefonica.net

Eye (London, England)
|April 26, 2008
PubMed
Summary

Optical coherence tomography (OCT) reveals significant optic disc cupping after optic neuritis. This increased cup-to-disc ratio, detected via OCT, correlates inversely with retinal nerve fiber layer thickness.

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Published on: September 22, 2017

Area of Science:

  • Ophthalmology
  • Neuro-ophthalmology
  • Medical Imaging

Background:

  • Optic neuritis is an inflammatory condition affecting the optic nerve.
  • Assessing structural changes in the optic disc post-optic neuritis is crucial for understanding long-term visual outcomes.
  • Optical coherence tomography (OCT) offers high-resolution imaging of the optic nerve head.

Purpose of the Study:

  • To investigate optic disc cupping following an episode of optic neuritis.
  • To quantify changes in optic disc morphology using optical coherence tomography (OCT).

Main Methods:

  • Study included 50 patients with unilateral optic neuritis and 50 matched controls.
  • Comprehensive eye examinations included visual acuity (VA), visual fields, and OCT of the optic nerve head.
  • Comparison of mean cup-to-disc (C/D) ratios between affected, fellow, and control eyes.

Main Results:

  • Affected eyes showed significantly larger mean C/D area ratio (CDAR), vertical C/D ratio (CDVR), and horizontal C/D ratio (CDHR) compared to fellow and control eyes.
  • Asymmetry in CDAR, CDVR, and CDHR exceeding 0.2 was observed in 24%, 28%, and 30% of patients, respectively.
  • A significant inverse correlation was found between C/D ratio asymmetry and retinal nerve fiber layer (RNFL) thickness.

Conclusions:

  • OCT can detect significant optic disc cupping after unilateral optic neuritis.
  • The increase in C/D ratio is inversely correlated with RNFL thickness and visual acuity.
  • These findings highlight structural changes detectable by OCT post-optic neuritis.