Related Experiment Video

Updated: Jul 5, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Stress-related mucosal disease in childhood appendicitis

Nick Lansdale1, Richard Hill, Stephen W Hancock

  • 1Paediatric Surgical Unit, Sheffield Children's Hospital, Western Bank, Sheffield, S10 2TH, UK. nicklansdale@doctors.org.uk

Pediatric Surgery International
|April 26, 2008
PubMed

Insights

Stress-related mucosal disease (SRMD) can occur in critically ill children with acute appendicitis. Prompt recognition and management are crucial to prevent severe complications like hemorrhage or perforation.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Critical Care Medicine

Background:

  • Stress-related mucosal disease (SRMD) is a known complication in critically ill patients.
  • Acute appendicitis is a common pediatric surgical emergency that can trigger SRMD.
  • SRMD in this context, though rare, carries significant risks.

Observation:

  • This review examines the incidence, etiology, risk factors, and management of SRMD.
  • The role of Helicobacter pylori in SRMD is discussed.
  • Three pediatric cases of ulcerative SRMD associated with complicated appendicitis are presented.

Findings:

  • Complicated appendicitis in children can lead to significant SRMD.
  • Hemorrhage and perforation are potential severe complications of SRMD.
  • Effective prophylaxis and management strategies are vital.

Implications:

  • Clinicians should consider SRMD in pediatric appendicitis cases, especially prolonged or complicated ones.
  • Early diagnosis and intervention can mitigate severe SRMD-related morbidity and mortality.
  • Further research into SRMD prevention and treatment in pediatric surgical patients is warranted.

More Related Videos

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

Related Concept Videos

Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...