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Updated: Jul 5, 2026

A Neonatal Mouse Model of Necrotizing Enterocolitis and Lamina Propria Isolation for Immune Cell Profiling
09:13

A Neonatal Mouse Model of Necrotizing Enterocolitis and Lamina Propria Isolation for Immune Cell Profiling

Published on: September 19, 2025

Unsuspected intestinal mucormycosis in a neonate presenting as necrotizing enterocolitis (NEC)

K K Dhingra1, S Mandal, N Khurana

  • 1Department of Pathology, Maulana Azad Medical College, New Delhi, India. kajaldhingra@yahoo.com

European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [Et Al] = Zeitschrift Fur Kinderchirurgie
|April 26, 2008
PubMed

Insights

Neonatal gastrointestinal mucormycosis is a rare, fatal condition often misdiagnosed as necrotizing enterocolitis (NEC). Early diagnosis and specific treatment are crucial for improving outcomes in affected newborns.

Area of Science:

  • Medical Mycology
  • Neonatology
  • Pediatric Surgery

Background:

  • Neonatal gastrointestinal tract (GIT) mucormycosis is a rare fungal infection.
  • It is frequently misdiagnosed as necrotizing enterocolitis (NEC), delaying critical treatment.
  • High mortality rates underscore the need for improved diagnostic strategies.

Observation:

  • A case of a 2-day-old infant with confirmed GIT mucormycosis is presented.
  • Diagnosis was established post-laparotomy and resection for presumed NEC.
  • A literature review of similar neonatal cases was conducted.

Findings:

  • Gastrointestinal mucormycosis in neonates presents diagnostic challenges.
  • Delayed diagnosis due to NEC misdiagnosis significantly impacts patient outcomes.
  • This condition requires specific antifungal therapy and surgical intervention.

Implications:

  • Highlights the importance of considering mucormycosis in the differential diagnosis of neonatal NEC.
  • Emphasizes the need for prompt recognition and targeted treatment to reduce mortality.
  • Suggests further research into early diagnostic markers for neonatal GIT mucormycosis.

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