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Related Concept Videos

Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

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Related Experiment Video

Updated: Jul 5, 2026

The Soft Agar Colony Formation Assay
08:01

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

WWOX tumor suppressor gene.

Jilong Yang1, Wei Zhang

  • 1Department of Bone and Soft Tissue Tumor, Tianjin Cancer Hospital and Institute, Tianjin Medical University, Tianjin, China.

Histology and Histopathology
|April 26, 2008
PubMed
Summary

The WWOX gene, implicated in various cancers, may function as a tumor suppressor. Its inactivation contributes to cancer development, though further research is needed to confirm its role.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • The WWOX gene, located at 16q23.3-24.1, is frequently altered in multiple cancers.
  • WWOX spans chromosomal fragile site 16D and encodes a 46 kDa protein.
  • Evidence suggests WWOX acts as a tumor suppressor, with inactivation contributing to tumorigenesis.

Purpose of the Study:

  • To investigate the role of the WWOX gene in cancer development.
  • To explore the tumor suppressor potential of WWOX.
  • To clarify the functional mechanisms of WWOX in neoplasia.

Main Methods:

  • Analysis of WWOX gene alterations in cancer cell lines and primary tumors.
  • Studies using WWOX gene knockout cancer cells.
  • Investigation of a WWOX knockout mouse model.

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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

Related Experiment Videos

Last Updated: Jul 5, 2026

The Soft Agar Colony Formation Assay
08:01

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

  • Identification of WWOX protein interacting partners.

    • Main Results:

    • Loss of heterozygosity and chromosomal rearrangements of WWOX are observed in ovarian, breast, hepatocellular, and prostate carcinomas.
    • WWOX knockout studies partially support its tumor suppressor hypothesis.
    • WWOX interacts with proteins involved in transcriptional regulation and apoptosis, notably c-Jun, TNF, p53, and E2F-1.
    • Apoptotic function appears more prominent than transcriptional repression.

    Conclusions:

    • WWOX inactivation is linked to cancer development, suggesting a tumor suppressor role.
    • WWOX likely mediates tumor suppression through apoptosis and transcriptional repression.
    • Further investigation is required to definitively establish WWOX as a tumor suppressor gene.