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Updated: Jul 5, 2026

Surgical Treatment of an Endolymphatic Sac Tumor
Published on: May 26, 2023
Neuroendocrine carcinoma of the jugular foramen
John P Leonetti1, Mobeen A Shirazi, Sam Marzo
1Department of Otolaryngology-Head and Neck Surgery, Skull Base Surgery Center, Maywood, IL 60153, USA. jleonet@lumc.edu
Abstract:
We describe what might have been the first reported case of a neuroendocrine carcinoma of the jugular foramen. A 50-year-old woman presented with progressive left-sided sensorineural hearing loss, vertigo, pulsatile tinnitus, headaches, and ataxia. Magnetic resonance imaging revealed a 4-cm left-sided jugular foramen tumor. The patient underwent near-total resection of the tumor. Despite lower cranial nerve preservation, postoperative paralysis of cranial nerves IX and X occurred, and vocal fold medialization was performed 5 days later. The final pathologic diagnosis was neuroendocrine carcinoma. The patient was treated with concurrent chemotherapy and intensity-modulated radiation therapy. This article will discuss the pathologic features and the management of jugular foramen tumors, along with the differential diagnosis of these rare tumors.
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