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Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: Jul 5, 2026

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Eicosanoids in asthma.

Kong-Sang Wan1, Wei-Fong Wu

  • 1Department of Pediatrics, Taipei City Hospital, Ren-ai Branch, Taipei, Taiwan. DXD40@tpech.gov.tw

Acta Paediatrica Taiwanica = Taiwan Er Ke Yi Xue Hui Za Zhi
|April 29, 2008
PubMed
Summary

Lipoxins (LXs) are endogenous anti-inflammatory mediators that counteract leukotrienes in asthma. They play a pivotal role in airway homeostasis and may offer a novel therapeutic approach for asthma treatment.

Area of Science:

  • Biochemistry
  • Immunology
  • Pulmonology

Background:

  • Eicosanoids are key mediators in asthma pathobiology, regulating airway inflammation and reactivity.
  • Lipoxins (LXs) are endogenous lipid mediators with anti-inflammatory properties, distinct from leukotrienes (LTs) and prostaglandins (PGs).
  • LTs are proinflammatory, while PGs have varied effects, with some causing bronchoconstriction only in asthmatics.

Purpose of the Study:

  • To elucidate the role of lipoxins (LXs) in airway inflammation and asthma.
  • To understand the mechanisms by which LXs exert their anti-inflammatory effects.
  • To explore the potential of LXs as a therapeutic strategy for asthma.

Main Methods:

  • Investigated the biosynthesis and function of lipoxins (LXs) in inflammatory sites.

Related Experiment Videos

Last Updated: Jul 5, 2026

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

  • Examined the interaction of lipoxin A4 (LXA4) with its receptors, CysLT1 and Aspirin-triggered lipoxin A4 (ALX) receptors.
  • Assessed the effects of LXA4 and ALX on cellular responses relevant to asthma, such as interleukin-8 release and calcium influx.

    • Main Results:

    • Lipoxins (LXs) were identified as endogenous agents that counter-regulate proinflammatory leukotrienes (LTs).
    • LXs activate the resolution of inflammatory responses in the airways.
    • Allergen challenge increases airway biosynthesis of lipoxin A4 (LXA4) and its receptor expression, indicating a role in allergic airway responses.

    Conclusions:

    • Lipoxins (LXs) are crucial for maintaining airway homeostasis.
    • LXs possess the potential to be developed as a novel therapeutic approach for human asthma.
    • Targeting LX pathways may offer a multipronged strategy for asthma management.