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Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
Sheila A Fisher1, Mark Tremelling, Carl A Anderson
1Department of Medical and Molecular Genetics, King's College London School of Medicine, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, UK.
Abstract:
We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.
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