Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be met...
Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation, vasodilation, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alzheimer's disease and its treatment-yesterday, today, and tomorrow.

Frontiers in pharmacology·2024
Same author

Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium.

Acta physiologica (Oxford, England)·2015
Same author

Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms.

British journal of pharmacology·2011
Same author

A comparative study of endothelin and sarafotoxin action in vascular and non-vascular smooth muscle.

Neurochemistry international·2010
Same author

Reduced EDHF responses and connexin activity in mesenteric arteries from the insulin-resistant obese Zucker rat.

Diabetologia·2008
Same author

Vascular smooth muscle relaxation mediated by nitric oxide donors: a comparison with acetylcholine, nitric oxide and nitroxyl ion.

British journal of pharmacology·2001

Related Experiment Video

Updated: Jul 5, 2026

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Defying the economists: a decrease in heart rate improves not only cardiac but also endothelial function.

C R Triggle1

  • 1Department of Pharmacology & Therapeutics, University of Calgary, Calgary, Alberta, Canada. cht2011@qatar-med.cornell.edu

British Journal of Pharmacology
|April 29, 2008
PubMed
Summary

Ivabradine, a specific inhibitor of the cardiac sinoatrial node I(f) current, improved blood vessel function in mice. These findings suggest potential benefits for treating endothelial dysfunction.

More Related Videos

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
07:49

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

Published on: July 21, 2023

Related Experiment Videos

Last Updated: Jul 5, 2026

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
07:49

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

Published on: July 21, 2023

Area of Science:

  • Pharmacology
  • Cardiovascular Physiology
  • Endothelial Function

Background:

  • Ivabradine is recognized for its therapeutic efficacy in cardiac ischemia.
  • It acts as a specific inhibitor of the cardiac sinoatrial node I(f) current.
  • Endothelial dysfunction is a critical factor in cardiovascular diseases.

Purpose of the Study:

  • To investigate the effects of chronic ivabradine treatment on endothelial function in a dyslipidemic mouse model.
  • To determine if the I(f) current inhibition by ivabradine influences endothelium-dependent vasodilation.
  • To explore potential benefits of I(f) current inhibitors beyond anti-ischemic effects.

Main Methods:

  • Utilized a dyslipidemic mouse model with human apoB-100 transgene.
  • Administered chronic treatment with ivabradine.
  • Assessed endothelium-dependent vasodilation in renal and cerebral arteries in response to acetylcholine (ACh).

Main Results:

  • Chronic ivabradine treatment significantly improved endothelium-dependent vasodilation to ACh in renal and cerebral arteries.
  • The beneficial effects on vasodilation were found to be secondary to a reduction in heart rate.
  • Ivabradine demonstrated efficacy in improving vascular function in a model of dyslipidemia.

Conclusions:

  • Drugs targeting the I(f) current, like ivabradine, may offer benefits in treating endothelial dysfunction.
  • The study highlights potential therapeutic applications of I(f) current inhibitors for conditions beyond cardiac ischemia.
  • Ivabradine's ability to improve endothelial function suggests a broader role in cardiovascular health management.