Antioxidants cannot suppress the lethal phenotype of a Drosophila melanogaster model of Huntington's disease

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A Simple One-step Dissection Protocol for Whole-mount Preparation of Adult Drosophila Brains
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Published on: December 1, 2016

Sepehr Bahadorani1, Arthur J Hilliker

  • 1Department of Biology, York University, Toronto, ON, Canada.

Genome
|April 29, 2008
PubMed

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Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...