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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: Jul 5, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Obesity and osteoarthritis.

Peter W Lementowski1, Stephen B Zelicof

  • 1Department of Orthopaedics, Long Island Jewish Hospital, New Hyde Park, New York, USA. lementop@hotmail.com

American Journal of Orthopedics (Belle Mead, N.J.)
|April 29, 2008
PubMed
Summary

Obesity significantly increases osteoarthritis (OA) risk. Bariatric surgery, leading to substantial weight loss, effectively relieved OA pain in 89% of patients, highlighting its therapeutic potential.

Area of Science:

  • Orthopedics
  • Public Health
  • Metabolic Surgery

Background:

  • Osteoarthritis (OA) is a primary cause of disability in the US.
  • Mechanical joint forces and obesity are significant, modifiable risk factors for OA.
  • Obesity affects 34 million US adults, with 13 million being morbidly obese.

Purpose of the Study:

  • To evaluate the impact of bariatric surgery on osteoarthritis pain.
  • To assess the efficacy of significant weight loss in managing OA symptoms.

Main Methods:

  • Review of patient outcomes following bariatric surgery.
  • Analysis of weight loss achieved through bariatric procedures.
  • Assessment of OA pain relief reported by patients post-surgery.

Related Experiment Videos

Last Updated: Jul 5, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Main Results:

  • Bariatric surgery leads to a mean weight loss of 44 kg (97 lb).
  • A 36% increased risk of knee OA for every 2-unit BMI increase was noted.
  • Complete relief of OA pain in at least one joint was reported by 89% of patients.

Conclusions:

  • Bariatric surgery is a highly effective intervention for reducing osteoarthritis-related disability.
  • Significant weight loss achieved through bariatric surgery provides substantial pain relief for OA patients.
  • Addressing obesity through bariatric surgery offers a promising strategy for managing OA.