Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Evolution of renin.

¹Hunterian Institute, Royal College of Surgeons of England, London, UK.

Hypertension (Dallas, Tex. : 1979)

|November 1, 1991

Summary

Researchers discovered renin, an enzyme linked to kidney disease and high blood pressure. This paper details how its function was uncovered and its connection to renal ischemia and hypertension.

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Medical Investigation of Retinal Vascular Occlusion.

British medical journal·2010

Same author

Effect of water restriction during adaptation to a low-sodium diet in man.

Clinical science (London, England : 1979)·1995

Same author

Effect of dietary salt restriction on renal sensitivity to vasopressin in man.

Clinical science (London, England : 1979)·1995

Same author

Control of sodium excretion in patients with cranial diabetes insipidus maintained on desamino-[8-D-arginine]vasopressin.

Clinical science (London, England : 1979)·1993

Same author

Effect of chronic low-dose arginine vasopressin infusion on body fluid homoeostasis during adaptation from a high- to a low-sodium diet in normal man.

Clinical science (London, England : 1979)·1993

Same author

Plasma renin activity and ischemic heart disease.

The New England journal of medicine·1993

Area of Science:

Nephrology
Endocrinology
Physiology

Background:

The link between high blood pressure and kidney disease was established following the advent of human blood pressure measurement.
19th-century medical practices involved organ extract injections to replace natural secretions.

Observation:

Tigerstedt and Bergman investigated the physiological effects of renal (kidney) extracts.
Their research led to the discovery of renin.

Findings:

This paper elucidates the methodologies employed to understand renin's mechanism of action.
The study explores the relationship between renin, renal ischemia, and the development of hypertension.

Implications:

Understanding renin's role is crucial for managing hypertension and kidney disease.
The discovery paved the way for future research into the renin-angiotensin system.