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HER2 codon 655 polymorphism and breast cancer risk: a meta-analysis
Weiyang Tao1, Chunyang Wang, Ruifa Han
1Department of Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Breast Cancer Research and Treatment
|April 29, 2008
Summary
The HER2 codon 655 Val allele is weakly associated with increased breast cancer risk. This single nucleotide polymorphism (SNP) may serve as a biomarker for Asian females or women aged 45 or younger.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The human epidermal growth factor receptor 2 (HER2) gene plays a role in cell growth.
- Polymorphisms in the HER2 gene may influence breast cancer susceptibility.
- The HER2 codon 655 polymorphism has been investigated for its association with breast cancer risk.
Purpose of the Study:
- To conduct a meta-analysis evaluating the association between the HER2 codon 655 polymorphism and breast cancer risk.
- To identify specific populations or subgroups where this association is significant.
Main Methods:
- A comprehensive literature search identified relevant case-control studies.
- Statistical analysis was performed using MIX 1.54 software.
- Included 20 eligible reports with 10,642 cases and 11,259 controls.
Main Results:
- Overall analysis showed a higher Val allele frequency in cases (OR=1.0921, P=0.0466).
- Significant associations were found in Asian populations across recessive, dominant, and co-dominant models.
- Increased susceptibility was observed in individuals aged ≤45 years under recessive and dominant models.
Conclusions:
- The HER2 codon 655 Val allele is weakly associated with an increased risk of breast cancer.
- The HER2 codon 655 single nucleotide polymorphism (SNP) may be a susceptibility biomarker for breast cancer in Asian females or women ≤45 years old.
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