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Updated: Jul 5, 2026

Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model
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Spread of Streptococcus suis sequence type 7, China.

Changyun Ye1, Xuemei Bai, Ji Zhang

  • 1State Key Laboratory for Infectious Disease Prevention and Control, Beijing, People's Republic of China.

Emerging Infectious Diseases
|April 29, 2008
PubMed
Summary

Streptococcus suis sequence type 7 (ST7) is spreading in China. The tetracycline-resistance gene tetM, found on transposon Tn916, was detected in most ST7 strains, suggesting horizontal gene transfer.

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Published on: December 23, 2022

Area of Science:

  • Veterinary Microbiology
  • Antimicrobial Resistance
  • Molecular Epidemiology

Background:

  • Streptococcus suis sequence type 7 (ST7) has emerged as a significant pathogen in China.
  • Understanding the genetic factors driving the spread of ST7 is crucial for public health.

Purpose of the Study:

  • To investigate the genetic basis for the emergence and spread of Streptococcus suis ST7 in China.
  • To identify key genetic elements, such as antibiotic resistance genes, associated with ST7 strains.

Main Methods:

  • Analysis of 114 Streptococcus suis isolates from China.
  • Detection and characterization of antimicrobial resistance genes, specifically the tetracycline-resistance gene tetM.
  • Identification of the genetic element carrying tetM, focusing on conjugative transposons like Tn916.

Main Results:

  • Out of 114 isolates, 106 were identified as ST7 strains.
  • The tetracycline-resistance gene tetM was present in all 106 ST7 strains.
  • The tetM gene was located on the conjugative transposon Tn916 in these strains.

Conclusions:

  • The tetracycline-resistance gene tetM, located on Tn916, is a common feature of emerging Streptococcus suis ST7 strains in China.
  • Horizontal transmission of the tetM gene via Tn916 is strongly suspected as a key event in the emergence and dissemination of ST7.
  • This finding has implications for antimicrobial resistance surveillance and control strategies for Streptococcus suis infections.