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Updated: Jul 5, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

Adverse childhood experiences and suicidal behavior.

Beth S Brodsky¹, Barbara Stanley

¹Department of Psychiatry, College of Physicians & Surgeons, Columbia University, NY, USA.

The Psychiatric Clinics of North America

|April 29, 2008

Summary

This summary is machine-generated.

Childhood abuse and neglect significantly increase the risk of suicidal behavior later in life. Research explores mediating factors, protective elements, and neurobiology to understand this link.

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Last Updated: Jul 5, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

Area of Science:

Psychiatry
Psychology
Neuroscience

Background:

Childhood physical and sexual abuse, and parental neglect are established risk factors for suicidal behavior.
Suicidal behavior presents a significant public health concern across adolescence and adulthood.

Purpose of the Study:

To review the relationship between childhood adverse experiences and suicidal behavior.
To explore mediating factors, protective elements, and neurobiological correlates.

Main Methods:

Review of correlational and retrospective studies.
Emphasis on recent prospective and familial transmission studies.
Discussion of neurobiological correlates of trauma.

Main Results:

Childhood abuse and neglect are significant risk factors for suicidal behavior.
Various factors mediate the relationship between childhood adversity and suicidal behavior.
Protective factors and personality traits can influence this relationship.

Conclusions:

Understanding the complex interplay of factors is crucial for preventing suicidal behavior.
Further research into mediating mechanisms and neurobiology can inform interventions.
Adverse childhood experiences represent a critical area for suicide prevention efforts.