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Expression of interleukin-10 in patients with adenomyosis
Fei Wang1, Hui Li, Zhongli Yang
1Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, People's Republic of China.
Objective:
To investigate the expression of interleukin-10 (IL-10) in adenomyosis.
Design:
Laboratory study using human tissue.
Setting:
University hospital.
Patient(S):
Thirty-four patients with adenomyosis and 30 women without adenomyosis who underwent hysterectomy for nonendometrial pathology.
Intervention(S):
Tissue sections were immunostained with murine monoclonal antihuman IL-10 antibodies.
Main Outcome Measure(S):
Microscopic evaluation to assess the presence and localization of IL-10 throughout the menstrual cycle in both eutopic endometrial and adenomyotic tissues of women with adenomyosis and compare it with IL-10 expression in the normal endometrium.
Result(S):
In the eutopic and ectopic endometrium of women with adenomyosis, epithelial cells showed higher staining intensity than the normal controls. However, no significant differences were found in the epithelial IL-10 immunostaining H score values between the eutopic endometrium and adenomyosis foci. Nonetheless, we observed a cyclic variation in the eutopic epithelial IL-10 immunoreactivity throughout the menstrual cycle with higher H score values in the secretory phase than in the proliferative phase.
Conclusion(S):
These findings suggest that an abnormality of inflammatory response may be present in the eutopic and ectopic endometrium of women with adenomyosis and that IL-10 may contribute to the pathogenesis and pathophysiology of adenomyosis.
