Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Formation by Endochondral Ossification

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...

Compact Bone

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...

Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

The Bone Matrix

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

Bones of the Upper Limb: Radius

Bones of the Upper Limb: Radius

The radius is longer of the two bones that make up the human antebrachium or forearm. At the proximal end, the radius articulates with the capitulum of the humerus and the radial notch of the ulna to form the elbow joint. At the distal end, the radius articulates with the ulna via the ulnar notch, forming the distal radioulnar joint. Distally, the radius also attaches to the carpal wrist bones (scaphoid and lunate) to form the radiocarpal joint.
The radius has a nail-shaped head, and a short...

Bones of the Upper Limb: Humerus

Bones of the Upper Limb: Humerus

The upper limb consists of the arm, forearm, wrist, and hand bones. The humerus is the single bone of the upper arm region. Proximally, it has a large, spherical, smooth head that articulates with the glenoid cavity of the scapula to form the glenohumeral or shoulder joint. The margin of the head is the anatomical neck, a residual epiphyseal plate. Laterally it extends to form bony projections called the greater tubercle and the lesser tubercle. Next to the tubercles is the surgical neck, a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Editorial: Prognostic factors for pain relief after CT-guided radiofrequency ablation of osteoid osteoma: a 13-year retrospective study.

Skeletal radiology·2026

Same author

Musculoskeletal Interventions: Where Were We, Where Are We, Where Are We Going?

Seminars in musculoskeletal radiology·2026

Same author

Management of Bone Marrow Edema with Interventional Radiology: When and How.

Seminars in musculoskeletal radiology·2026

Same author

Percutaneous Cryoablation for the Management of Bone and Soft Tissue Tumors.

Seminars in musculoskeletal radiology·2026

Same author

Peripheral Nerve Ultrasound-guided Intervention: From the Basics to Sonosurgery.

Seminars in musculoskeletal radiology·2026

Same author

Multimodal Percutaneous Treatment of an Aggressive Intraosseous Hemangioma of the Pelvis.

Seminars in musculoskeletal radiology·2026

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

Diffuse mineralization of forearm extraskeletal chondroma.

Thomas Le Corroller¹, Corinne Bouvier-Labit, Pierre Champsaur

¹Department of Radiology, La Timone Hospital, Marseille, France. thomas.lecorroller@ap-hm.fr

Joint Bone Spine

|April 29, 2008

Summary

This study details a rare case of extraskeletal chondroma with diffuse matrix calcification. Radiologic and histologic findings aid in diagnosing this unusual soft-tissue tumor.

Related Experiment Videos

Last Updated: Jul 5, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

Area of Science:

Orthopedic Oncology
Radiology
Soft Tissue Pathology

Background:

Extraskeletal chondromas are rare benign cartilaginous tumors arising outside the skeleton.
Diffuse calcification of the chondroid matrix is an uncommon feature, posing diagnostic challenges.
Accurate diagnosis is crucial for appropriate management and to differentiate from malignant neoplasms.

Observation:

A case of extraskeletal chondroma in the left flexor digitalis profundus is presented.
Computed tomography (CT) and magnetic resonance (MR) imaging revealed a well-demarcated, low signal intensity mass on T2-weighted MR images.
Associated findings included slight surrounding intramuscular edema.

Findings:

Histopathological examination confirmed a heavily calcified soft-tissue chondroma.
A macrophagic foreign body reaction was noted, likely secondary to the extensive calcification.
The diffuse calcification pattern represents an unusual mineralization of the chondroid matrix.

Implications:

Recognizing this specific pattern of diffuse matrix calcification is vital for accurate radiological diagnosis of extraskeletal chondroma.
This knowledge can help radiologists differentiate extraskeletal chondromas from other soft-tissue masses, including malignancies.
Further understanding of such rare presentations can improve diagnostic confidence and patient outcomes.