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Updated: Jul 5, 2026
03:05
Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
Non-invasive tests in gastric diseases
1Section of Gastroenterology, Department of Clinical Sciences, University of Parma, Italy. francesco.dimario@unipr.it
Summary
Serological biomarkers like pepsinogens and gastrin can identify individuals at risk for gastric inflammation and atrophy, aiding early detection of gastric cancer precursors.
Area of Science:
- Gastroenterology
- Oncology
- Biomarker Discovery
Background:
- Gastric cancer, despite decreasing incidence, is a major cause of cancer mortality.
- Early diagnosis is challenging due to insidious development and advanced-stage presentation.
- Reliable non-invasive biomarkers for early gastric neoplasia detection are lacking.
Purpose of the Study:
- To review serological biomarkers for detecting gastric mucosa alterations.
- To analyze clinical studies on serological markers for gastric cancer risk assessment.
Main Methods:
- Review of existing literature on serological parameters.
- Analysis of biomarkers including serum pepsinogens I and II, gastrin-17, cytokines, and antibodies.
- Correlation of serological levels with gastric atrophy and inflammation.
Main Results:
- Low pepsinogen I and PGI/PGII ratio with high gastrin-17 indicate corpus atrophic gastritis.
- Low gastrin-17 suggests antral atrophic gastritis.
- Plasmatic ghrelin levels correlate with corpus atrophy.
- Anti-Helicobacter pylori IgG, CagA antibodies, and PGII detect gastric inflammation.
Conclusions:
- Serological parameters can identify individuals at risk for gastric inflammation and atrophy.
- These markers may help select subjects for further investigation of gastric neoplasia.
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