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Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
Published on: September 21, 2021
Diffuse cortical atrophy in a marmoset model of multiple sclerosis
Ian M Pomeroy1, Elaine K Jordan, Joseph A Frank
1Department of Clinical Neurology, University of Oxford, Oxford, UK. ian.pomeroy@nhs.net
Neuroscience Letters
|April 29, 2008
Summary
Cortical atrophy in marmoset experimental autoimmune encephalomyelitis (EAE) models is diffuse, not solely linked to focal demyelination. This suggests broader factors contribute to cortical thinning in demyelinating diseases.
Area of Science:
- Neuroscience
- Immunology
- Pathology
Background:
- Marmoset experimental autoimmune encephalomyelitis (EAE) models MS-like white and grey matter lesions.
- Cortical atrophy is a feature of multiple sclerosis (MS), but its cause in EAE models is unclear.
Purpose of the Study:
- To investigate cortical atrophy in marmoset EAE.
- To determine if cortical thinning correlates with focal demyelinated lesions.
Main Methods:
- EAE was induced in marmosets.
- Cortical thickness was measured around focal lesions and compared to control animals.
- Lesion characteristics (leucocortical, subpial) were identified.
Main Results:
- A diffuse 13-21% loss of cortical thickness was observed in EAE marmosets compared to controls.
- No significant difference in cortical thinning was found between demyelinated and myelinated areas within EAE cortex.
- Findings were independent of age, sex, and disease duration.
Conclusions:
- Localized cortical demyelination does not account for the majority of observed atrophy in marmoset EAE.
- Diffuse or remote factors likely drive cortical thinning in this model.
- Marmoset EAE is a valuable tool for studying cortical loss in demyelinating diseases.
