Renovascular hypertension in children

Kjell Tullus1, Eileen Brennan, George Hamilton

  • 1Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK. tulluk@gosh.nhs.uk

PubMed

Insights

Renovascular disease, a rare cause of pediatric hypertension, often faces diagnostic delays. Prompt intervention, including endovascular procedures or surgery, can effectively manage high blood pressure in children.

Area of Science:

  • Pediatric Nephrology
  • Vascular Medicine
  • Cardiology

Background:

  • Renovascular disease is an uncommon yet significant cause of hypertension in children.
  • Delayed diagnosis is frequent due to infrequent blood pressure monitoring and dismissal of high readings in pediatric patients.
  • Associated abnormalities in other major blood vessels are common in children with renovascular disease.

Purpose of the Study:

  • To summarize the diagnostic and therapeutic approaches for renovascular disease in children.
  • To highlight the importance of early detection and multidisciplinary management.
  • To review the effectiveness of current treatment modalities.

Main Methods:

  • Review of diagnostic imaging techniques including CT, MRI, and renal scintigraphy with angiotensin-converting-enzyme inhibition.
  • Angiography as the gold standard for diagnosis.
  • Discussion of interventional and surgical treatment options.

Main Results:

  • Endovascular treatment, with or without stenting, successfully cures or reduces hypertension in over 50% of affected children.
  • Surgical intervention is recommended when necessary, ideally delayed until skeletal maturity.
  • Multidisciplinary team management leads to favorable long-term outcomes.

Conclusions:

  • Early recognition and timely intervention are crucial for managing pediatric renovascular hypertension.
  • Both endovascular and surgical treatments offer significant benefits.
  • A collaborative approach involving pediatric nephrologists, interventional radiologists, and vascular surgeons optimizes long-term results.

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