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A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Renovascular hypertension in children
Kjell Tullus1, Eileen Brennan, George Hamilton
1Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK. tulluk@gosh.nhs.uk
Insights
Renovascular disease, a rare cause of pediatric hypertension, often faces diagnostic delays. Prompt intervention, including endovascular procedures or surgery, can effectively manage high blood pressure in children.
Area of Science:
- Pediatric Nephrology
- Vascular Medicine
- Cardiology
Background:
- Renovascular disease is an uncommon yet significant cause of hypertension in children.
- Delayed diagnosis is frequent due to infrequent blood pressure monitoring and dismissal of high readings in pediatric patients.
- Associated abnormalities in other major blood vessels are common in children with renovascular disease.
Purpose of the Study:
- To summarize the diagnostic and therapeutic approaches for renovascular disease in children.
- To highlight the importance of early detection and multidisciplinary management.
- To review the effectiveness of current treatment modalities.
Main Methods:
- Review of diagnostic imaging techniques including CT, MRI, and renal scintigraphy with angiotensin-converting-enzyme inhibition.
- Angiography as the gold standard for diagnosis.
- Discussion of interventional and surgical treatment options.
Main Results:
- Endovascular treatment, with or without stenting, successfully cures or reduces hypertension in over 50% of affected children.
- Surgical intervention is recommended when necessary, ideally delayed until skeletal maturity.
- Multidisciplinary team management leads to favorable long-term outcomes.
Conclusions:
- Early recognition and timely intervention are crucial for managing pediatric renovascular hypertension.
- Both endovascular and surgical treatments offer significant benefits.
- A collaborative approach involving pediatric nephrologists, interventional radiologists, and vascular surgeons optimizes long-term results.
Abstract:
Renovascular disease is an uncommon but important cause of hypertension in children. It is usually diagnosed after a long delay because blood pressure is infrequently measured in children and high values are generally dismissed as inaccurate. Many children with renovascular disease have abnormalities of other blood vessels (aorta, cerebral, intestinal, or iliac). Individuals suspected of having the disorder can be investigated further with CT, MRI, or renal scintigraphy done before and after administration of an angiotensin-converting-enzyme inhibitor, but angiography is still the gold standard. Most children with renovascular disease will need interventional or surgical treatment. Endovascular treatment with or without stenting will cure or reduce high blood pressure in more than half of all affected children. Surgical intervention, if needed, should be delayed preferably until an age when the child is fully grown. Modern treatment provided by a multidisciplinary team of paediatric nephrologists, interventional radiologists, and vascular surgeons offers good long-term treatment results.
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