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Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
Biliary sequelae following radioembolization with Yttrium-90 microspheres
Bassel Atassi1, Affaan K Bangash, Robert J Lewandowski
1Department of Radiology, Section of Interventional Radiology, Robert H. Lurie Comprehensive Cancer Center, Northwestern Memorial Hospital, 676 North St. Clair Street, Suite 800, Chicago, Illinois 60611, USA.
Journal of Vascular and Interventional Radiology : JVIR
|April 29, 2008
Summary
Yttrium-90 (90Y) radioembolization for liver cancer shows acceptable biliary toxicities. Biliary complications like necrosis and stricture occurred in 10.1% of patients, with few requiring intervention.
Area of Science:
- Hepatobiliary imaging and intervention
- Interventional oncology
- Radiology
Background:
- Yttrium-90 (90Y) radioembolization is a key treatment for hepatocellular carcinoma (HCC) and liver metastases.
- Assessing treatment-related complications is crucial for patient management.
Purpose of the Study:
- To describe the spectrum and incidence of biliary sequelae after intraarterial 90Y therapy.
- To evaluate the safety profile of 90Y radioembolization concerning biliary complications.
Main Methods:
- Retrospective analysis of 327 patients undergoing 90Y therapy for HCC or liver metastases.
- Pre- and post-treatment imaging, liver function tests, and bilirubin levels were monitored.
- Biliary sequelae were assessed via CT and MRI 3-6 months post-treatment.
Main Results:
- Biliary sequelae were observed in 10.1% of patients (33/327), including biliary necrosis, biloma, cholecystitis, and strictures.
- Grade 3/4 bilirubin toxicities occurred in 9.5% of patients (31/327).
- Only 1.8% of patients (6/327) required unplanned interventions for biliary complications.
Conclusions:
- 90Y radioembolization demonstrates an acceptable rate of biliary toxicities in patients with HCC or liver metastases.
- While generally safe, careful monitoring for biliary complications is warranted.
- Further research into long-term biliary outcomes is recommended.
