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Expression of microRNAs during embryonic development of Xenopus tropicalis

James C Walker1, Richard M Harland

  • 1Department of Molecular and Cell Biology, 579 Life Sciences Addition, University of California, Berkeley, CA 94720-3200, USA.

Gene Expression Patterns : GEP
|April 29, 2008
PubMed

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MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...