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Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis

Carla Esposito1, Maxim V Pethoukov, Dmitri I Svergun

  • 1Istituto di Biostrutture e Bioimmagini, C.N.R., I-80134, Napoli, Italy.

Journal of Bacteriology
|April 29, 2008
PubMed

Heparin-binding hemagglutinin (HBHA) is a virulence factor of tuberculosis which is responsible for extrapulmonary dissemination of this disease. A thorough biochemical characterization of HBHA has provided experimental evidence of a coiled-coil nature of HBHA. These data, together with the low-resolution structures of a full-length form and a truncated form of HBHA obtained by small-angle X-ray scattering, have unambiguously indicated that HBHA has a dimeric structure with an elongated shape.

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