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Bacterial Peptide Display for the Selection of Novel Biotinylating Enzymes
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Retargeting R-type pyocins to generate novel bactericidal protein complexes

Steven R Williams1, Dana Gebhart, David W Martin

  • 1AvidBiotics Corporation, 385 Oyster Point Blvd., Suite 6A, South San Francisco, CA 94080, USA.

Applied and Environmental Microbiology
|April 29, 2008
PubMed
Summary

Researchers engineered R-type pyocins, potent antimicrobials, by modifying their tail fibers. This retargeting broadens their antibacterial spectrum, offering a promising alternative to conventional antibiotics with minimal impact on beneficial bacteria.

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