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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Updated: Jul 5, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
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Syphilitic uveitis: an Asian perspective.

A Anshu1, C L Cheng, S-P Chee

  • 1Singapore National Eye Centre, Third Hospital Avenue, Singapore 168751.

The British Journal of Ophthalmology
|April 29, 2008
PubMed
Summary
This summary is machine-generated.

Syphilitic uveitis often presents as non-granulomatous inflammation, even with rising infectious syphilis rates. Testing for syphilis is recommended for uveitis cases, including anterior uveitis.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Immunology

Background:

  • Syphilis, a sexually transmitted infection, can affect the eye, leading to syphilitic uveitis.
  • Understanding the clinical patterns and incidence trends of syphilitic uveitis is crucial for timely diagnosis and management.

Purpose of the Study:

  • To investigate the clinical features of syphilitic uveitis in a specific patient population.
  • To analyze trends in the incidence of ocular syphilis at a tertiary referral center.

Main Methods:

  • Retrospective case series of 22 patients diagnosed with syphilitic uveitis.
  • Data collected from the Ocular Inflammation and Immunology Services of the Singapore National Eye Centre (1995-2006).
  • Review of patient demographics, clinical presentations, and serological test results (positive fluorescent treponemal antibody absorption test).

Main Results:

  • The study included 22 patients (mean age 52.7 years) with confirmed syphilis and no HIV co-infection.
  • Non-granulomatous anterior uveitis was the most common presentation (62.06%).
  • Posterior uveitis, intermediate uveitis, and panuveitis were also observed. Vitritis was the most frequent posterior segment finding (65.4%).
  • Most patients (86.4%) had latent syphilis. No significant increase in ocular syphilis cases was noted over the decade.

Conclusions:

  • Despite a resurgence of infectious syphilis, a dramatic increase in syphilitic uveitis cases was not observed at this center.
  • Syphilitic uveitis commonly manifests as non-granulomatous inflammation.
  • Ophthalmologists should consider syphilis serology in patients presenting with uveitis, particularly anterior uveitis.