Related Experiment Video
Updated: Jul 5, 2026
In Vivo Methods to Assess Retinal Ganglion Cell and Optic Nerve Function and Structure in Large Animals
Published on: February 26, 2022
Recording focal macular photopic negative response (PhNR) from monkeys
Mineo Kondo1, Yukihide Kurimoto, Takao Sakai
1Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan. kondomi@med.nagoya-u.ac.jp
Purpose:
To record the photopic negative response (PhNR) of the focal electroretinograms (ERGs) from the macula of monkeys and to study the properties of the focal macular PhNRs.
Methods:
Focal macular ERGs were recorded from five rhesus monkeys using a modified infrared fundus camera, in which a red stimulus spot on a blue illuminated background were incorporated. The effects of different stimulus intensities and durations presented on a steady blue background of 100 scot cd/m(2) on the focal macular PhNRs were investigated. Focal macular PhNRs were also recorded before and after an intravitreous injection of tetrodotoxin (TTX).
Results:
Focal ERG responses from a photocoagulated retinal site were recordable when the luminance of the red stimulus spot was
Conclusions:
It is possible to record focal macular PhNRs from monkeys by using a red stimulus spot on a blue background. Investigations of focal PhNRs can be a useful method of studying inner retinal function of local areas in normal and diseased retinas.
