[Quality of life in sarcoidosis--validation of a new instrument]

To validate SHQ in Russia on a limited sampling of patients with sarcoidosis.

Initially a formal analogue of original SHQ version in Russian was developed, after that culture compatibility was tested on a limited group of patients with proven sarcoidosis (development step). During the validation step of current study a new set (34 patients) filled draft SHQ version twice with time interval about two weeks. During the first visit, a Russian validated version of SF-36 Questionnaire additionally was filled. For each case a special Case Report form was completed, where different objective parameters were filed.

Destination volume of sample according to hypothesis parameters (alpha = 0.05, p = 0.80) reached 32 cases, final sample volume was 34, no valid distinctions between double SHQ assessments were found for all questionnaire subscales (p > 0.05). A valid positive correlation link was found between most subscales of reference (SF-36) and validated instruments (r = 0.41 0.83). Three of objective parameters (PaO2, DL(CO) and aspartate-transaminase) have shown positive correlation with SHQ subscales (r = 0.43, 0.36, 0.34, respectively). Cronbach 's alpha meaning was 0.9049, mean inter-item correlation reached 0.78732

On the basis of original SHQ instrument the first Russian HRQL instrument for sarcoidosis was developed and validated. Current instrument has shown high reproducibility and specificity as well as reliability and integrity, but further studies are needed to investigate changes of LQ according to different therapy variants and abilities of current instrument in this field.