Related Experiment Video

Updated: Jul 5, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
05:25

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Published on: September 15, 2023

[Revascularization of myocardium: coronary artery bypass grafting or stenting?]

V B Simonenko, I A Borisov, A N Bletkin

    Klinicheskaia Meditsina
    |April 30, 2008
    PubMed

    Insights

    Coronary artery bypass grafting (CABG) showed better long-term results than coronary angioplasty and stenting (CAS) over five years. CABG demonstrated superior survival rates and reduced instances of restenosis and angina compared to CAS, especially bare-metal stents.

    Area of Science:

    • Cardiovascular Surgery
    • Interventional Cardiology
    • Clinical Outcomes Research

    Context:

    • Coronary heart disease (CHD) management involves surgical and interventional approaches.
    • Long-term comparative data between coronary artery bypass grafting (CABG) and coronary angioplasty and stenting (CAS) are crucial for treatment decisions.
    • Evaluating outcomes of different stenting technologies (drug-eluting vs. bare-metal) is essential.

    Purpose:

    • To conduct a comparative analysis of the 5-year clinical outcomes for patients with coronary heart disease treated with CABG versus CAS.
    • To assess survival rates, restenosis, myocardial infarction, and angina pectoris incidence between CABG and different CAS groups.
    • To compare the efficacy of drug-eluting stents versus bare-metal stents within the CAS cohort.

    Summary:

    • A 5-year follow-up of 1100 CHD patients revealed higher survival rates for CABG (85.9%) compared to CAS (84.1% for drug-eluting stents, 70.8% for bare-metal stents).
    • Coronary angioplasty and stenting (CAS) showed higher rates of restenosis and myocardial infarction, particularly with bare-metal stents.
    • Angina pectoris was significantly less frequent at 1 year in CABG patients (62%) than in CAS patients (46.7% and 24.3%).

    Impact:

    • Coronary artery bypass grafting (CABG) demonstrates a relatively better clinical effect over 5 years for coronary heart disease management.
    • Newer generation drug-eluting stents show improved outcomes compared to bare-metal stents in CAS procedures.
    • Findings support the consideration of CABG for long-term benefits in specific patient populations with coronary heart disease.

    More Related Videos

    A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis04:30

    A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

    Published on: May 14, 2013

    Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery09:12

    Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

    Published on: March 27, 2018

    Related Concept Videos

    Coronary Artery Disease V: Interprofessional Care01:27

    Coronary Artery Disease V: Interprofessional Care

    Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
    Acute Coronary Syndrome IV: Interprofessional Care01:28

    Acute Coronary Syndrome IV: Interprofessional Care

    IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
    Angina IV: Management01:26

    Angina IV: Management

    IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
    Peripheral Artery Disease III: Interprofessional Care01:27

    Peripheral Artery Disease III: Interprofessional Care

    Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
    Mitral Stenosis III: Medical Management01:26

    Mitral Stenosis III: Medical Management

    Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
    Acute Coronary Syndrome I: Introduction01:30

    Acute Coronary Syndrome I: Introduction

    Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...