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Updated: Jul 5, 2026
Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
[Clinical observation on 899 children infected with intestinal nematodes and treated with tribendimidine enteric
Shu-hua Xiao1, Zhong-xing Wu, Jian-hui Zhang
1NatiNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China.
Insights
Tribendimidine effectively treats children with hookworm and Ascaris lumbricoides infections. This single-dose treatment showed high cure rates and minimal side effects in clinical trials.
Area of Science:
- Clinical pharmacology
- Infectious diseases
- Pediatric medicine
Background:
- Helminth infections like hookworm and Ascaris lumbricoides significantly impact child health globally.
- Effective and safe anthelmintic treatments are crucial for pediatric populations.
Purpose of the Study:
- To assess the efficacy and safety of tribendimidine in treating children with hookworm and Ascaris lumbricoides infections.
- To determine the cure and effective rates for these specific helminth infections.
Main Methods:
- A multi-center, open-label clinical trial involving 899 children aged 4-14 years.
- Diagnosis of helminth infections using the improved Kato-Katz method.
- Treatment with a single oral dose of 200 mg tribendimidine enteric-coated tablet.
Main Results:
- High cure rates for hookworm (82.0%) and Ascaris lumbricoides (95.0%) infections.
- Effective rates were 99.2% for hookworm and 99.8% for Ascaris lumbricoides.
- Tribendimidine demonstrated a low adverse effect rate (1.6%) with mild, transient side effects.
Conclusions:
- Single-dose tribendimidine (200 mg) is effective and safe for treating pediatric hookworm and Ascaris lumbricoides infections.
- The drug exhibits a favorable safety profile with minimal adverse events.
- Further evaluation of efficacy against Trichuris trichiura is warranted.
Objective:
To evaluate the efficacy and safety of tribendimidine in treatment of children with hookworm and Ascaris lumbricoides infections.
Methods:
An open and multi-center clinical trial was conducted in the provinces of Hainan, Sichuan and Guizhou. 899 children aged 4-14 years were enrolled in the study. Hookworm, A. lumbricoides or other helminth infections were diagnosed by improved Kato-Katz method. All the patients were treated orally with tribendimidine enteric coated tablet at a single dose of 200 mg. The efficacy was evaluated by stool examination 3-4 weeks post treatment.
Results:
The cure rate and effective rate of the children with hookworm infection were 82.0% (433/528) and 99.2% (524/528), respectively, while in children with A. lumbricoides infection, they were 95.0% (576/639) and 99.8% (637/639), respectively. The efficacy of tribendimidine enteric coated tablet given to the children with Trichuris trichiura infection at a single dose of 200 mg was 36.8% (112/304). The adverse effect induced by tribendimidine, such as dizziness, nausea and vomiting, was light and transient with an adverse effect rate of 1.6% (14/899). No apparent impact was seen on the blood and urine routine examination, hepatic and renal function as well as ECG examination. Conclusion Tribendimidine given at a single dose of 200 mg exhibits lower adverse effect rate and potential efficacy in the treatment of children with hookworm and A. lumbricoides infections.
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