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Updated: Jul 5, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Mitral valve abnormalities in hypertrophic cardiomyopathy: echocardiographic features and surgical outcomes
Ryan K Kaple1, Ross T Murphy, Linda M DiPaola
1Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic, Cleveland, Ohio 44195, USA.
Insights
Mitral valve (MV) abnormalities are common in hypertrophic cardiomyopathy (HCM). Echocardiography can predict successful MV repair, which is durable but feasible in only about half of HCM patients.
Area of Science:
- Cardiology
- Cardiac Surgery
- Medical Imaging
Background:
- Mitral valve (MV) abnormalities are frequent in hypertrophic cardiomyopathy (HCM).
- Surgical indications for MV intervention in HCM are not fully defined.
- This study investigates echocardiographic predictors of MV repairability and outcomes in HCM.
Purpose of the Study:
- To define echocardiographic features of MV pathology in HCM patients.
- To correlate these features with MV repairability, procedures, durability, and survival.
- To identify predictors of successful mitral valve repair in HCM.
Main Methods:
- Analysis of 784 echocardiograms from 115 HCM patients undergoing MV procedures (1986-2003).
- Detailed assessment of MV morphology and associated pathologies.
- Outcomes evaluated via cross-sectional follow-up.
Main Results:
- 67 patients (58%) had MV repair, 48 (42%) had MV replacement.
- Long leaflets and degenerative pathology predicted successful repair.
- The anterior mitral leaflet was significantly longer in the repair group (3.0 cm vs 2.5 cm).
- 91% of repaired patients were free of reoperation by 3 years.
Conclusions:
- Intrinsic MV pathology is common in symptomatic HCM patients undergoing myectomy.
- Echocardiography identifies features predictive of successful MV repair.
- MV repair is durable but feasible in approximately 50% of HCM patients.
Background:
Functional and intrinsic mitral valve (MV) abnormalities are common in hypertrophic cardiomyopathy (HCM); however, morphologic characteristics constituting indications for surgical intervention are incompletely defined. This study was conducted to define the echocardiographic features of MV pathology in patients with HCM and relate these to repairability of the MV, MV procedures performed, durability of repair, and survival.
Methods:
From 1986 to 2003, 851 patients with HCM underwent operation, and 115 had a concomitant MV procedure. Detailed analysis of their 784 transthoracic and transesophageal echocardiograms, performed intraoperatively and postoperatively, was conducted. Outcomes were assessed by cross-sectional follow-up.
Results:
Sixty-seven patients (58%) underwent MV repair, and 48 (42%) had MV replacement. The mean left ventricular outflow tract peak gradient was 70 +/- 50 mm Hg. Systolic anterior motion was present in 95%. Valve abnormalities were degenerative in 36 (31%), myxomatous in 23 (20%), papillary muscle in 23 (20%), restrictive chordal in 22 (19%), restrictive leaflet in 80 (70%), and long leaflet in 64 (56%). Patients undergoing MV repair had higher prevalence of long leaflets and degenerative MV pathology. The anterior mitral leaflet was 3.0 +/- 0.49 cm in the repair group vs 2.5 +/- 0.40 cm in the replacement group (p = 0.0001). MV replacement patients were older, more symptomatic, and had more renal dysfunction and lower hematocrits. By 3 years, 91% of patients with a repair were free of reoperation.
Conclusions:
Intrinsic MV pathology is frequently observed in HCM patients with symptomatic obstruction who undergo myectomy. Echocardiography can identify MV features predictive of successful valve repair. Repair, although durable, is feasible in only about half of patients.
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