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Related Concept Videos

Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
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[Granulomatous reactions from aesthetic dermal micro-implants].

F Rongioletti1

  • 1Clinica Dermatologica, DISEM, Università di Genova, viale Benedetto XV,7 16132 Gênes, Italie. Franco.Rongioletti@unihe.it

Annales De Dermatologie Et De Venereologie
|May 6, 2008
PubMed
Summary

Granulomatous reactions to dermal fillers are rare but can occur years after injection. Histopathology is crucial for diagnosing these reactions and identifying filler particles, aiding in challenging cases.

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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

Area of Science:

  • Dermatology
  • Pathology
  • Aesthetic Medicine

Background:

  • Granulomatous reactions are a rare complication of dermal fillers for tissue augmentation.
  • These reactions can occur with both permanent and biodegradable fillers, sometimes manifesting years after injection.
  • Clinical diagnosis can be challenging due to patient history or lack of information.

Purpose of the Study:

  • To present and discuss the clinical and microscopic features of granulomatous reactions to dermal fillers.
  • To explore the pathogenesis of these delayed complications.
  • To outline treatment strategies for granulomatous reactions.

Main Methods:

  • Review of clinical presentations of granulomatous reactions to dermal fillers.
  • Histopathological analysis to identify filler particles and characterize granuloma formation.
  • Discussion of diagnostic challenges and expert consultation in identifying filler materials.

Main Results:

  • Histopathology is the definitive method for diagnosing granulomatous reactions and identifying filler particles.
  • The morphology of vacuoles and cystic structures within granulomas correlates with the shape of injected filler particles.
  • Delayed reactions can occur up to 18 years post-injection, complicating diagnosis.

Conclusions:

  • Granulomatous reactions to dermal fillers, though rare, necessitate accurate diagnosis.
  • Histopathology is essential for identifying filler types and confirming diagnosis.
  • Understanding the features and pathogenesis aids in managing these challenging aesthetic complications.